This guide distills key lessons learned about scaling and sustaining innovation from ten projects involved in the Teagle Foundation’s “Faculty Work and Student Learning in the 21st Century” grant initiative. The grants were awarded in 2012-2013 to consortia and collaboratives of colleges (not formally a part of a consortium) as part of this initiative. The key focus of these grants was: how can and should faculty work change in response to the changing conditions—indeed, the changing nature—of undergraduate liberal education? And, how can liberal arts colleges maintain a quality, high-impact learning environment within a changing and challenging environment that requires innovation?